Retinopatia por Tamoxifeno. Uma Complicação Incomum, mas Grave: Relato de Caso

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Publicado: Oct 29, 2024
DOI: https://doi.org/10.52600/2763-583X.bjcr.2025.5.1.bjcr31
Palavras-chave:
Tamoxifeno, Retinopatia, Toxicidade ocular, Maculopatia

Conteúdo do artigo principal

Lucas Linhares Pierre
Faculdade de Medicina UNINTA
Lara Linhares Pierre
Faculdade de Medicina UNINTA
Paulo de Tarso Ponte Pierre-Filho
Clínica Pierre Oftalmologia
https://orcid.org/0000-0002-1018-0709

Resumo

Tamoxifen is a selective estrogen receptor modulator most widely used in the treatment of hormone-dependent breast cancer. We describe a case of a 51-year-old woman treated with tamoxifen for 4 years who had gradual diminution of vision in both eyes of three months duration. On examination, visual acuity was 20/40 in the right eye and 20/50 in the left eye. A fundus examination revealed bilateral symmetric crystalline deposits in the macula. There were characteristic structural changes on spectral domain-optical coherence tomography, including abnormalities of the ellipsoid zone and outer nuclear layer.  Subsequently, tamoxifen was switched to anastrozole. Despite cessation of tamoxifen, her vision did not improve. The clinical presentation of tamoxifen retinopathy is discussed, along with the importance of regular ophthalmic examination for individuals receiving tamoxifen, even in low doses.

Detalhes do artigo

Como Citar
Pierre, L. . L., Pierre, L. L., & Pierre-Filho, P. de T. P. (2024). Retinopatia por Tamoxifeno. Uma Complicação Incomum, mas Grave: Relato de Caso. Brazilian Journal of Case Reports, 5(1), bjcr31. https://doi.org/10.52600/2763-583X.bjcr.2025.5.1.bjcr31
Edição
v. 5 n. 1 (2025): January/December - 2025
Seção
Clinical Case Reports
Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Biografia do Autor

Lucas Linhares Pierre, Faculdade de Medicina UNINTA

Faculdade de Medicina UNINTA, Sobral, Ceará, Brasil.

Lara Linhares Pierre, Faculdade de Medicina UNINTA

Faculdade de Medicina UNINTA, Sobral, Ceará, Brasil.

Paulo de Tarso Ponte Pierre-Filho, Clínica Pierre Oftalmologia

Clínica Pierre Oftalmologia, Sobral, Ceará, Brasil.

Referências

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