Effective Multimodal Therapy for Chemically Aggravated Androgenetic Alopecia: A Case Report using PRP and Mesotherapy

Main Article Content

Poliana Laís Zanetti Andrade
Fernanda Roberta Casagrande Tomachevski
Aureanna Nairne Negrão Murakami
Andre Gaspar Zinco
https://orcid.org/0000-0001-8831-3703
Fábio Seigi Murakami
https://orcid.org/0000-0002-6238-3604

Abstract

Androgenetic alopecia (AGA) is a common condition characterized by progressive hair loss, closely associated with androgen hormone activity and genetic predisposition. Although platelet-rich plasma (PRP) therapy has gained attention for its regenerative potential and ability to stimulate follicular activity, the synergistic effect of combining PRP with mesotherapy remains unexplored. This case report presents a successful protocol involving a male patient with advanced AGA whose condition was further aggravated by chemical damage from a bleaching procedure. The therapeutic protocol included intradermal injections of PRP in combination with customized blends of active ingredients by mesotherapy, administered in multiple sessions. Quantitative photographic analysis revealed a visual increase in hair density, along with notable improvements in hair thickness and scalp health. The patient expressed great satisfaction with both the aesthetic results and scalp comfort. These results demonstrate the potential of an integrative PRP-mesotherapy approach as safe and effective treatment for patients with complex androgenetic alopecia.

Article Details

How to Cite
Andrade, P. L. Z., Tomachevski, F. R. C., Murakami, A. N. N., Zinco, A. G., & Murakami, F. S. (2025). Effective Multimodal Therapy for Chemically Aggravated Androgenetic Alopecia: A Case Report using PRP and Mesotherapy. Brazilian Journal of Case Reports, 6(1), bjcr117. https://doi.org/10.52600/2763-583X.bjcr.2026.6.1.bjcr117
Section
Clinical Case Reports
Author Biographies

Poliana Laís Zanetti Andrade, Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná

Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná, Curitiba, Paraná, Brazil.

Fernanda Roberta Casagrande Tomachevski, Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná

Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná, Curitiba, Paraná, Brazil.

Aureanna Nairne Negrão Murakami, Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná

Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná, Curitiba, Paraná, Brazil.

Andre Gaspar Zinco, Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná

Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná, Curitiba, Paraná, Brazil.

Fábio Seigi Murakami, Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná

Aesthetic Research Laboratory, Postgraduate Program in Pharmaceutical Sciences, Department of Pharmacy, Federal University of Paraná, Curitiba, Paraná, Brazil.

References

Sinclair RD, Yazdabadi A. Male and female pattern hair loss: Pathophysiology, diagnosis, and management. Dermatol Clin. 2015;33(1):119–128. doi:10.1016/j.det.2014.09.002.

Fischer DL, Han H, Gade A, Nestor MS. Treatment options for androgenetic alopecia: Efficacy, side effects, compliance, financial considerations, and ethics. J Cosmet Dermatol. 2021;20(12):3759–3781. doi:10.1111/jocd.14537.

Gupta AK, Mays RR, Versteeg SG, Shear NH, Piguet V, Foley KA. Efficacy of non-surgical treatments for androgenetic alopecia: A systematic review and network meta-analysis. J Eur Acad Dermatol Venereol. 2018;32(2):211–222. doi:10.1111/jdv.14627.

Alves R, Grimalt R. Platelet-rich plasma in combination with 5% minoxidil topical solution in male androgenetic alopecia: A randomized placebo-controlled study. Dermatol Ther. 2018;31(5):e12652. doi:10.1111/dth.12652.

Gentile P, Garcovich S, Bielli A, Scioli MG, Orlandi A, Cervelli V. The effect of platelet-rich plasma in hair regrowth: A randomized placebo-controlled trial. Stem Cells Int. 2019;2019:1095291. doi:10.1155/2019/1095291.

Fabbrocini G, Leone A, Cantelli M, De Vita V, Pellacani G, Monfrecola G. PRP and AGA: Point of view. Dermatol Ther. 2020;33(6):e13685. doi:10.1111/dth.13685.

Rodrigues BL, Montalvão AL. Mesotherapy in the treatment of alopecia: A literature review. J Cosmet Dermatol. 2019;18(6):1699–1704. doi:10.1111/jocd.12970.

Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through image analysis. Dermatol Surg. 2019;45(7):933–940. doi:10.1097/DSS.0000000000001586.

Najafizade E, Jamali AK, Zahraei SAH. Mesotherapy vs PRP: Hair loss. J Clin Images Med Case Rep. 2021;2(6):1518. doi:10.52768/2766-7820/1518.

Hausauer AK, Jones DH. PRP and microneedling in aesthetic medicine. New York: Thieme; 2019. doi:10.1055/b-006-163721.