Botulinum Toxin A Delivery via MMP Technique: An Emerging Therapeutic Approach for Frontal Fibrosing Alopecia

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Published: Jun 29, 2023
DOI: https://doi.org/10.52600/2763-583X.bjcr.2024.4.1.3-7
Keywords:
Frontal Fibrosing Alopecia, Botulinum toxin A, microinfusion, MMP, treatment

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Simone Ramos Nogueira Guerra Neri
Brazilian Society of Dermatology
https://orcid.org/0009-0004-7380-4795
Marta de Oliveira Domingos
Laboratory of Bacteriology, Instituto Butantan
https://orcid.org/0000-0003-4492-0709
Nílceo Schwery Michalany
Department of Pathology Laboratory of Pathological Anatomy, Federal University of São Paulo (UNIFESP)
Alexandre Ozores Michalany
Department of Dermatology, University of Santo Amaro (UNISA)
Celia Luiza Petersen Vitello Kalil
Dermatology Services, Federal University of Fronteira Sul
https://orcid.org/0000-0002-1294-547X

Abstract

Frontal Fibrosing Alopecia (FFA) is a disease of unknown etiology and pathogenesis whose prevalence has been increasing since its first description in 1994. With no cure, treatments only control the inflammatory process and disease progression, but do not reverse the changes induced by it. We report the case of a patient with early-stage FFA who underwent three monthly sessions of 30 units of Botulinum Toxin Type A administered by MMP® (Microinfusion of drugs through the skin) technique. The results showed a substantial improvement in the patient's clinical condition with inhibition of the inflammatory process and an evident increase in follicular density in the treated area.

Article Details

How to Cite
Neri, S. R. N. G., Domingos, M. de O., Michalany, N. S., Michalany, A. O., & Kalil, C. L. P. V. (2023). Botulinum Toxin A Delivery via MMP Technique: An Emerging Therapeutic Approach for Frontal Fibrosing Alopecia. Brazilian Journal of Case Reports, 4(1), 3–7. https://doi.org/10.52600/2763-583X.bjcr.2024.4.1.3-7
Issue
Vol. 4 No. 1 (2024): January/March - 2024
Section
Clinical Case Reports
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This work is licensed under a Creative Commons Attribution 4.0 International License.

Author Biographies

Simone Ramos Nogueira Guerra Neri, Brazilian Society of Dermatology

Brazilian Society of Dermatology, São Paulo, Brazil.

Marta de Oliveira Domingos, Laboratory of Bacteriology, Instituto Butantan

Laboratory of Bacteriology, Instituto Butantan, São Paulo, SP, Brazil.

Nílceo Schwery Michalany, Department of Pathology Laboratory of Pathological Anatomy, Federal University of São Paulo (UNIFESP)

Department of Pathology Laboratory of Pathological Anatomy, Federal University of São Paulo (UNIFESP), São Paulo, SP, Brazil.

Alexandre Ozores Michalany, Department of Dermatology, University of Santo Amaro (UNISA)

Department of Dermatology, University of Santo Amaro (UNISA), São Paulo, SP, Brazil.

Celia Luiza Petersen Vitello Kalil, Dermatology Services, Federal University of Fronteira Sul

Dermatology Services, Federal University of Fronteira Sul, Passo Fundo, RS, Brazil.

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